An effective strategy to prevent allopurinol-induced hypersensitivity by HLA typing.

Jae-Woo JungHye-Ryun KangHeung-Woo ParkKook-Hwan OhKwon-Wook JooYon-Su KimCurie AhnKyung Wha LeeSang-Heon ChoKyung-Up MinHye-Ryun Kang

Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2015)

This study shows the usefulness of HLA-B*58:01 screening in identifying patients at high risk for the development of allopurinol-induced SCARs and suggests that application of a tolerance induction protocol or alternative medications could be an effective strategy to prevent allopurinol-induced SCARs in HLA-B*58:01-positive patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
high glucose
chronic kidney disease
diabetic rats
drug induced
prognostic factors
randomized controlled trial
oxidative stress
patient reported outcomes
platelet rich plasma