Predictive value of topoisomerase II alpha protein for clinicopathological characteristics and prognosis in early breast cancer.

Yun WuYiqun HanQing LiPin ZhangPeng YuanYang LuoYing FanShanshan ChenRuigang CaiQiao LiHangcheng XuYan WangFei MaJiayu WangBinghe Xu

Published in: Breast cancer research and treatment (2022)

To our knowledge, this is the first study to recommend the optimal cut-off value of TOP2A expression in breast cancer. The TOP2A expression is significantly correlated with HER2 status, Ki67 index, tumor size, histologic grade and HR status, and could be a surrogate indicator for poor prognosis of early breast cancer.

Keyphrases

poor prognosis
early breast cancer
long non coding rna
healthcare
binding protein
neoadjuvant chemotherapy
radiation therapy
protein protein
breast cancer risk