SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinoma.
Chiaki T IshidaStephanie L MyersWei ShaoMeredith R McGuireChune LiuCasie S KubotaTheodore E EwachiwDebaditya MukhopadhyaySuqi KeHao WangZeshaan A RasheedRobert A AndersPeter J EspenshadePublished in: bioRxiv : the preprint server for biology (2024)
Our findings demonstrate that SREBP pathway activation is a critical part of the metabolic reprogramming that occurs in PDAC development and progression. Therefore, targeting the SREBP pathway has significant therapeutic potential.
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