Analysis of evolutionary and genetic patterns in structural genes of primate lentiviruses.
Myeongji ChoXianglan MinHyeon S SonPublished in: Genes & genomics (2022)
The origin viruses of HIV (SIVcpz_gor and SIVsmm) exhibit greater similarity to human codon usage in the gag gene, confirming their robust adaptability to human codon usage. Therefore, HIV1 and HIV2 may have evolved to avoid human codon usage by selection pressure in the gag gene after interspecies transmission from SIV hosts to humans. By overcoming safety and stability issues, information from codon usage analysis will be useful for attenuated HIV1 vaccine development. A recoded HIV1 variant can be used as a vaccine vector or in immunotherapy to induce specific innate immune responses. Further research regarding HIV1 dinucleotide usage and codon pair usage will facilitate new approaches to the treatment of AIDS.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hiv aids
- hepatitis c virus
- men who have sex with men
- immune response
- endothelial cells
- genome wide
- healthcare
- copy number
- gene expression
- dna methylation
- inflammatory response
- dendritic cells
- transcription factor
- pluripotent stem cells
- combination therapy