Sodium selenite modulates global activation of proinflammatory M1-like macrophages, necroinflammation and M1-like/M2-like dichotomy at the onset of human type 1 diabetes.

Ss exerts a potent immunomodulatory role on functional activities of human proinflammatory T1D M1-like Mϕs subjected to extended activation, as well as on the M1-like/M2-like dichotomy. Additionally, the current study provides a novel therapeutic approach using Ss to promote the anti-inflammatory function of Mϕs at the onset of T1D.