Effect of Opicapone on Levodopa Pharmacokinetics in Patients with Fluctuating Parkinson's Disease.
Joaquim José FerreiraWerner PoeweOlivier RascolFabrizio StocchiAngelo AntoniniJoana MoreiraBruno GuimarãesJosé-Francisco RochaPatrício Soares-da-SilvaPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
Combining opicapone 50 mg with a 100 mg lower daily dose of levodopa provides higher levodopa bioavailability with avoidance of trough levels. Despite the lower levodopa dose, modifying the levodopa pharmacokinetic profile with opicapone was associated with decreased off time and increased on time. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.