The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma.
Dapeng HaoGuangchun HanAnsam SinjabLorena Isabel Gomez-BolanosRossana LazcanoAlejandra Griselda SerranoSharia D HernandezEnyu DaiXuanye CaoJian HuMinghao DangRuiping WangYanshuo ChuXingzhi SongJianhua ZhangEdwin Roger Parra CuentesJennifer A WargoStephen G SwisherCascone TinaBoris SepesiP Andrew FutrealMingyao LiSteven M DubinettJunya FujimotoLuisa Maren Solis SotoIgnacio I WistubaChristopher S StevensonAvrum E SpiraShabnam ShalapourHumam KadaraLinghua WangPublished in: Cancer discovery (2022)
While TIBs are highly enriched in LUADs, they are poorly characterized. This study provides a much-needed understanding of the transcriptional, clonotypic states and phenotypes of TIBs, unraveling their potential roles in the immunopathology of early-stage LUADs and constituting a road map for the development of TIB-targeted immunotherapies for the treatment of this morbid malignancy. This article is highlighted in the In This Issue feature, p. 2483.