Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity.

Yanping WangSungyong YouShengchen SuAustin YeonEric M LoSungjin KimJames L MohlerMichael R FreemanHyung Lae Kim

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Lowering serum cholesterol decreased signaling through mTORC2 and enhanced antitumor CD8+ T-cell memory. We provide a rationale for large-scale clinical testing of cholesterol lowering strategies for prostate cancer chemoprevention.

Keyphrases

low density lipoprotein
prostate cancer
randomized controlled trial
clinical trial
cell proliferation
working memory