Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry.

Lisa Vermij Jan J JobsenAlicia León-CastilloMariel BrinkhuisSuzan RoothaanMelanie E PowellStephanie M de BoerPearly KhawLinda R MileshkinAnthony FylesAlexandra LearyCatherine GenestieIna M Jürgenliemk-SchulzEmma J CrosbieHelen J MackayHans W NijmanRemi A NoutVincent T H B M SmitCarien L CreutzbergNanda HorewegTjalling Bossenull null

Published in: British journal of cancer (2023)

We confirmed the prognostic impact of the molecular classification, age, stage, and adjuvant CTRT in a large cohort of high-risk EC. ER-positivity is a strong favourable prognostic factor in NSMP HR-EC and identifies a homogeneous subgroup of NSMP tumours. Assessment of ER status in high-risk NSMP EC is feasible in clinical practice and could improve risk stratification and treatment.

Keyphrases

prognostic factors
clinical practice
early stage
estrogen receptor
endoplasmic reticulum
deep learning
breast cancer cells
genome wide
randomized controlled trial
dna methylation
gene expression
combination therapy
replacement therapy
phase iii