Inhibition of receptor-interacting protein kinase-3 in the necroptosis pathway attenuates inflammatory bone loss in experimental apical periodontitis in Balb/c mice.

Jie LiuJiajia WangJie RenQin YangWeicheng ZhanMin WangLiang HaoYuan Yue

Published in: International endodontic journal (2021)

Necroptosis may be involved in AP progression. RIP3 inhibition ameliorated the expression of inflammatory cytokines and bone resorption in Fn-induced AP lesions in Balb/c mice.

Keyphrases

bone loss
protein kinase
high fat diet induced
transcription factor
poor prognosis
oxidative stress
binding protein
high glucose
diabetic rats
bone mineral density
metabolic syndrome
wild type
endothelial cells
skeletal muscle
body composition
stress induced