Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells.

Paola Bianchi GuimarãesRafael Filippelli da SilvaCarolina Caldas HoffLiliam FernandesClovis Ryuichi NakaieJair Ribeiro ChagasAdriana Karaoglanovic CarmonaMichael BaderJoão Bosco Pesquero

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)

Our data show that kinin B1R positively modulates both CPM expression and activity, suggesting that CPM-B1R interaction in membrane microdomains might affect enzyme activity, beyond interfering in receptors signaling. This work highlights the interactions among different components of KKS and contributes to a better understanding of its patho-physiological role.

Keyphrases

endothelial cells
poor prognosis
binding protein
electronic health record
big data
high glucose
long non coding rna
machine learning
deep learning