Characterization of Cardiac Function by Echocardiographic Global Longitudinal Strain in a Cohort of Children with Neurofibromatosis Type 1 Treated with Selumetinib.
Thomas CaiffaAntimo TessitoreAndrea MagnolatoMatilde PetzMarco BobboDaniela ChiccoBiancamaria D'Agata MottoleseAldostefano PorcariEgidio BarbiGianfranco SinagraIrene BrunoPublished in: Paediatric drugs (2022)
Patients with NF1 treated with selumetinib may experience subtle changes in systolic function identified by global longitudinal strain and not revealed by left ventricular ejection fraction. Global longitudinal strain might be useful to monitor cardiac function in this cohort of patients for the duration of therapy.
Keyphrases
- ejection fraction
- aortic stenosis
- left ventricular
- cross sectional
- heart failure
- newly diagnosed
- end stage renal disease
- blood pressure
- young adults
- signaling pathway
- chronic kidney disease
- acute myocardial infarction
- hypertrophic cardiomyopathy
- oxidative stress
- immune response
- mitral valve
- cardiac resynchronization therapy
- peritoneal dialysis
- lps induced
- patient reported outcomes
- bone marrow
- nuclear factor
- mesenchymal stem cells
- replacement therapy