Characterization of a novel mouse platelet transfusion model.

Dominique GordyTheresa SwayneGregory J BerryTiffany A ThomasKrystalyn E HudsonElizabeth F Stone

Published in: Vox sanguinis (2024)

We developed mouse platelets for transfusion analogous to human platelet units using a modified PRP collection protocol with maximum storage of 1 day for an 'old' unit. This provides a powerful tool to test how process modifications and storage conditions affect transfused platelet function in vivo.

Keyphrases

cardiac surgery
endothelial cells
randomized controlled trial
sickle cell disease
red blood cell
acute kidney injury
platelet rich plasma