Target-based discovery of antagonists of the tick (Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit midgut contractions.

Bianca Monteiro Henriques-SantosDwight BakerNian ZhouThomas SnavelyJames C SacchettiniPatricia Victoria Pietrantonio

Published in: Pest management science (2024)

Molecules identified through this approach could be useful probes for studying the tick kinin signaling system and midgut physiology. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Keyphrases

small molecule
aedes aegypti
public health
genome wide
high throughput
fluorescence imaging
living cells
zika virus
single molecule
randomized controlled trial
gene expression
binding protein
photodynamic therapy
meta analyses
nucleic acid