Development of a high-throughput γ-H2AX assay based on imaging flow cytometry.
Younghyun LeeQi WangIgor ShuryakDavid J BrennerHelen C TurnerPublished in: Radiation oncology (London, England) (2019)
The results indicate that the IFC-based γ-H2AX protocol may provide a practical and high-throughput platform for measurements of individual global DNA DSB repair capacity which can facilitate precision medicine by predicting individual radiosensitivity and risk of developing adverse effects related to radiotherapy treatment.