Anti-osteoporosis activity of casticin in ovariectomized rats.

Dong Zhang Jianmin Li Xuejia Li Wanxin Liu Ying Yu Hao Sun Jiajun Wu Zhichao Ge Kai Lv Yanting Shao Shuqiang Wang Xiaojian Ye

Published in: Toxicology research (2024)

Casticin improved bone density, bone biomechanics, the level of calcium and estrogen, the release of pro-inflammatory factor and oxidative stress to alleviate osteoporosis, which was associated with the upregulation of Nrf2/HO-1 pathway.

Keyphrases

bone mineral density
oxidative stress
postmenopausal women
bone loss
body composition
dna damage
poor prognosis
soft tissue
bone regeneration
diabetic rats
induced apoptosis
estrogen receptor
signaling pathway
long non coding rna
heat shock