Trait impulsivity in Juvenile Myoclonic Epilepsy.
Amy ShakeshaftNaim PanjwaniRobert McDowallHolly CrudgingtonJavier Peña CeballosDanielle M AndradeChristoph P BeierChoong Yi FongJoanna GescheDavid A GreenbergKhalid HamandiJeanette KohtKheng Seang LimAlessandro OrsiniMark I ReesGuido RubboliKaja K SelmerAnna B SmithPasquale StrianoMarte SyvertsenInga TalvikRhys H ThomasJana ZarubovaMark P RichardsonLisa J StrugDeb K Palnull nullPublished in: Annals of clinical and translational neurology (2020)
Trait impulsivity is elevated in JME and comparable to scores in personality and neurotic disorders. Increased seizure frequency and absence of circadian seizure pattern moderate BIS score, suggesting disruption of both cortico-striatal and thalamocortical networks as a shared mechanism between seizures and impulsivity in JME. These findings warrant consideration of impulsivity as a distinct target of intervention, and as a stratifying factor for AED treatment in JME, and perhaps other types of epilepsy. The role of impulsivity in treatment adherence and psychosocial outcome requires further investigation.