Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride-rich lipoprotein metabolism.

Audrey Deprince Nathalie Hennuyer Sander KooijmanAmanda C M PronkEric BaugéViktor LienardAn VerrijkenEveline DirinckLuisa Vonghia Eloïse WoitrainNiels J KloosterhuisEléonore MarezPauline JacquemainJustina Clarinda Wolters Fanny Lalloyer Delphine Eberlé Sandrine QuemenerEmmanuelle VallezAnne Tailleux Mostafa KouachJean-Francois GoossensVioleta RaverdyBruno DerudasJan Albert KuivenhovenMikaël Croyal Bart van de Sluis Sven M Francque Francois Pattou Patrick C N Rensen Bart Staels Joel T Haas

Published in: Hepatology (Baltimore, Md.) (2022)

These data reveal a previously undescribed role for ApoF in the control of plasma and hepatic lipoprotein metabolism by favoring VLDL-TG secretion and hepatic lipoprotein remnant particle clearance.

Keyphrases

low density lipoprotein
high fat diet
single cell
genome wide
big data
gene expression
metabolic syndrome
machine learning
deep learning
high fat diet induced