Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis.

María Del Mar GilV AccurtiB SantacruzMaria N PlanaK H Nicolaides

Published in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2017)

Screening by analysis of cfDNA in maternal blood in singleton pregnancies could detect > 99% of fetuses with trisomy 21, 98% of trisomy 18 and 99% of trisomy 13 at a combined FPR of 0.13%. The number of reported cases of SCA is too small for accurate assessment of performance of screening. In twin pregnancies, performance of screening for trisomy 21 is encouraging but the number of cases reported is small. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

Keyphrases

gestational age
birth weight
systematic review
preterm birth
pregnancy outcomes
randomized controlled trial
meta analyses
high resolution
pregnant women