High nuclear expression of HIF1α, synergizing with inactivation of LIMD1 and VHL, portray worst prognosis among the bladder cancer patients: association with arsenic prevalence.
Mukta BasuAmvrin ChatterjeeBalarko ChakrabortyEssha ChatterjeeSabnam GhoshSudip SamadderDilip Kumar PalAnup RoyJayanta ChakrabartiAmlan GhoshChinmay Kumar PandaPublished in: Journal of cancer research and clinical oncology (2021)
To conclude, MIBC samples portrayed higher alterations in VHL and LIMD1, thereby, stabilizing HIF1α protein and lowering the OS of patients.