A comparison of BMP2 delivery by coacervate and gene therapy for promoting human muscle-derived stem cell-mediated articular cartilage repair.

Xueqin GaoHaizi ChengHassan AwadaYing TangSarah AmraAiping LuXuying SunGuijin LvCharles HuardBing WangXiaohong BiYadong WangXueqin Gao

Published in: Stem cell research & therapy (2019)

We conclude that the delivery of hMDSCs and BMP2 with the coacervate technology can achieve a similar cartilage repair relative to lenti-BMP2/GFP-mediated gene therapy. The use of coacervate technology to deliver BMP2/sFLT1 with hMDSCs for cartilage repair holds promise for possible clinical translation into an effective treatment modality for osteoarthritis and traumatic cartilage injury.

Keyphrases

mesenchymal stem cells
gene therapy
bone regeneration
stem cells
extracellular matrix
endothelial cells
spinal cord injury
big data
genome wide
machine learning
copy number
induced pluripotent stem cells
pluripotent stem cells
transcription factor
deep learning
genome wide identification