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Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice.

Hong WangSara KuuselaRita Rinnankoski-TuikkaVincent DumontRim BouslamaUsama Abo RamadanJo WaalerAnni-Maija LindenNai-Wen ChiStefan KraussEija PirinenSanna H Lehtonen
Published in: International journal of obesity (2005) (2020)
Our study unravels a novel molecular mechanism whereby pharmacological inhibition of TNKS in obesity and diabetes enhances oxidative metabolism and ameliorates lipid disorder. This happens via tissue-specific PGC-1α-driven transcriptional reprogramming in muscle and WAT, without affecting liver. This highlights inhibition of TNKS as a potential pharmacotherapy for obesity and T2DM.
Keyphrases
  • high fat diet induced
  • skeletal muscle
  • type diabetes
  • insulin resistance
  • metabolic syndrome
  • weight loss
  • cardiovascular disease
  • weight gain
  • glycemic control
  • gene expression
  • mouse model
  • fatty acid
  • physical activity