Expression of Toll-like receptors (TLRs) in the lungs of an experimental sepsis mouse model.
Anargyros BakopoulosAlkistis KapelouzouDiamantis I TsilimigrasMichalis KatsimpoulasDimitrios SchizasChrysostomos AravanisEvaggelos BalafasManolis MavroidisKitty PavlakisAnastasios MachairasTheodore LiakakosPublished in: PloS one (2017)
TLRs seem to be highly expressed in the lungs of septic mice, therefore suggesting a potential role in the pathogenesis of ARDS during sepsis. While more studies need to be conducted in order to completely understand the underlying mechanisms, TLRs may represent a promising target for establishing novel therapeutic strategies in the treatment of sepsis.