Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis.

Jian-Qiao HongYang-Xin WangSi-Hao LiGuang-Yao JiangBin HuYu-Te YangJia-Hong MengShi-Gui Yan

Published in: Journal of orthopaedic surgery and research (2018)

The current meta-analysis revealed that the G variant of SMAD3 rs12901499 polymorphism increased the risk of OA in Caucasians. Further well-designed studies with larger sample size in different ethnic populations are required to confirm these results.

Keyphrases

systematic review
case control
transforming growth factor
epithelial mesenchymal transition
knee osteoarthritis
meta analyses
rheumatoid arthritis
single cell
randomized controlled trial