Amphiregulin Expression Is a Predictive Biomarker for EGFR Inhibition in Metastatic Colorectal Cancer: Combined Analysis of Three Randomized Trials.

Arndt Stahler Sebastian Stinzing Dominik Paul ModestIngrid RicardClemens Giessen-JungChristine KapaunBoryana IvanovaFlorian KaiserLudwig Fischer von WeikersthalNicolas MoosmannAndreas SchalhornMartina StauchAlexander KianiSwantje HeldThomas DeckerMarkus MoehlerJens NeumannThomas KirchnerAndreas JungVolker Heinemann

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

High AREG mRNA expression is a favorable prognostic biomarker for mCRC which interacted significantly with efficacy of anti-EGFR treatment.

Keyphrases

metastatic colorectal cancer
small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
poor prognosis
binding protein
long non coding rna
combination therapy
replacement therapy