Leishmania infantum induces high phagocytic capacity and intracellular nitric oxide production by human proinflammatory monocyte.

Christiana Vargas RibeiroBruna Fonte Boa RochaEdward OliveiraAndrea Teixeira-CarvalhoOlindo Assis Martins-FilhoSilvane Maria Fonseca MurtaVanessa Peruhype-Magalhães

Published in: Memorias do Instituto Oswaldo Cruz (2020)

Our results showed that L. braziliensis and L. infantum induce different innate immune responses and a highly inflammatory profile, which is characteristic of infection by L. infantum, the species associated with visceral disease.

Keyphrases

immune response
nitric oxide
endothelial cells
dendritic cells
oxidative stress
insulin resistance
toll like receptor
hydrogen peroxide
nitric oxide synthase
pluripotent stem cells
metabolic syndrome
skeletal muscle
inflammatory response
adipose tissue