Promoter DNA Hypermethylation of the Cysteine Dioxygenase 1 (CDO1) Gene in Intraductal Papillary Mucinous Neoplasm (IPMN).

Yoshiki FujiyamaYusuke KumamotoNobuyuki NishizawaShuji NakamotoHiroki HaradaKazuko YokotaYoko TanakaKazuharu IgarashiHironobu OikiKosuke OkuwakiTomohisa IwaiSabine KajitaHiroyuki TakahashiHiroshi TajimaTakashi KaizuJiichiro SasakiMasahiko WatanabeKeishi Yamashita

Published in: Annals of surgical oncology (2020)

CDO1 promoter hypermethylation is extremely specific to IPMN and may accumulate with IPMN tumor progression during the adenoma-carcinoma sequence. It might be a promising candidate as a diagnostic marker of pancreatic cystic diseases.

Keyphrases

dna methylation
low grade
transcription factor
gene expression
genome wide
poor prognosis
copy number
cell free
single molecule
high grade
fluorescent probe
nucleic acid
long non coding rna