Exploring Thresholds and Interaction Effects Among Antibiotic Usage, Covariates, and their Effect on Antibiotic Resistance using an Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Case.
Mamoon A AldeyabZainab Said Al-HashimyMubarak Al-YaqoobiBarbara R ConwayFeras Darwish ElhajjiStuart E BondElizabeth A LattyakSyed Shahzad HasanWilliam J LattyakPublished in: Expert review of anti-infective therapy (2023)
The Interaction model increased effectiveness to explain variation of ESBL-producing K. pneumoniae incidence rates while showing the importance of exploring interactions when modeling the relationship between antibiotic use, covariates (ABHR), and resistance in hospitals. The main-effect thresholds in third-generation cephalosporins and ABHR, and the identified interaction between third generation cephalosporins and ABHR, can inform effective hospital antimicrobial stewardship.