A GWAS meta-analysis of alpha angle suggests cam-type morphology may be a specific feature of hip osteoarthritis in older adults.
Benjamin G FaberMonika FryszApril E HartleyRaja EbsimCindy G BoerFiona R SaundersJennifer S GregoryRichard M AspdenNicholas C HarveyLorraine SouthamWilliam GilesChristine L Le MaitreJeremy Mark WilkinsonJoyce B J van MeursEleftheria ZegginiTimothy CootesClaudia LindnerJohn P KempGeorge Davey SmithJonathan H TobiasPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
Expected observational associations between AA and related clinical outcomes provided face-validity for the DXA-derived AA measures. Evidence of bidirectional associations between AA and HOA, particularly in the reverse direction, suggests that hip shape modelling secondary to a genetic predisposition to HOA contributes to the well-established relationship between HOA and cam morphology in older adults.
Keyphrases
- systematic review
- physical activity
- total hip arthroplasty
- body composition
- meta analyses
- rheumatoid arthritis
- machine learning
- high resolution
- bone mineral density
- deep learning
- genome wide
- knee osteoarthritis
- magnetic resonance imaging
- cross sectional
- computed tomography
- gene expression
- case control
- mass spectrometry
- postmenopausal women