Elevated plasma miR-210 expression is associated with atypical genitalia in patients with 46,XY differences in sex development.
Felipe Martins EliasMirian Yumie NishiMaria Helena Palma SirciliRafael Loch BastistaNathalia Lisboa GomesMaria Tereza Martins FerrariElaine Maria Frade CostaFrancisco Tibor DenesBerenice Bilharinho MendoncaSorahia DomenicePublished in: Molecular genetics & genomic medicine (2022)
Our study showed a positive association between the presence of atypical genitalia and plasma levels of miR-210 expression in the group of patients with 46,XY DSD of unknown aetiology studied. These findings contribute to reveal a new perspective on the role of miRNAs in the development of male external genitalia and the broad spectrum of phenotypes presented by patients with 46,XY DSD.