DNA hypermethylation of GDF5 in developmental dysplasia of the hip (DDH).

Taghi BaghdadiMohammad NejadhosseinianReza ShirkoohiReza Mostafavi TabatabaeeSeyed S TamehriMojtaba SaffariSeyed Mohammad Javad Mortazavi

Published in: Molecular genetics & genomic medicine (2019)

Our study showed that the methylation status of the GDF5 in patients with DDH is dysregulated. This dysregulation indicates that adjustment in the methylation might modify the expression of this gene. Since this gene plays an essential role in cartilage and bone development, thus reducing its expression can contribute to the pathogenesis of DDH. Further studies are needed to elucidate the role of GDF5 in this disease.

Keyphrases

genome wide
poor prognosis
dna methylation
copy number
binding protein
genome wide identification
single molecule
bone mineral density
circulating tumor
extracellular matrix
nucleic acid