Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans.

Hang Sun Xingchun Wang Jiaqi Chen Aaron M GusdonKexiu SongLiang LiShen Qu

Published in: International journal of endocrinology (2018)

It was concluded that melatonin could improve cutaneous symptoms in obese patients with acanthosis nigricans by improving insulin sensitivity and inflammatory status. This trial is registered with ClinicalTrials.gov NCT02604095.

Keyphrases

adipose tissue
insulin resistance
metabolic syndrome
type diabetes
weight loss
obese patients
clinical trial
high fat diet
oxidative stress
study protocol
phase iii
bariatric surgery
randomized controlled trial
combination therapy
replacement therapy
depressive symptoms
high fat diet induced