Apoptotic and genotoxic effects of low-intensity ultrasound on healthy and leukemic human peripheral mononuclear blood cells.
Timur SalievDinara BegimbetovaDinara BaiskhanovaDanysh AbetovUlykbek KairovCharles P GilmanBakhyt MatkarimovKatsuro TachibanaPublished in: Journal of medical ultrasonics (2001) (2017)
The study demonstrated that low-intensity ultrasound selectively induced apoptosis in cancer PMBCs. Ultrasound-induced DNA damage was observed primarily in leukemic PMBCs. Nevertheless, both cell lines were able to repair ultrasound-mediated DNA strand breaks.
Keyphrases
- induced apoptosis
- magnetic resonance imaging
- endoplasmic reticulum stress
- oxidative stress
- dna damage
- signaling pathway
- endothelial cells
- acute myeloid leukemia
- contrast enhanced ultrasound
- ultrasound guided
- diabetic rats
- high glucose
- squamous cell carcinoma
- computed tomography
- papillary thyroid
- circulating tumor
- cell proliferation
- peripheral blood
- anti inflammatory
- induced pluripotent stem cells
- pluripotent stem cells