Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer-induced cachexia.
Rianne D W VaesDavid P J van DijkTessa T J WelbersMarinus J BlokMerel R AberleLara HeijSylvia F BojSteven W M Olde DaminkSander S RensenPublished in: Journal of cachexia, sarcopenia and muscle (2020)
This novel human pancreatic tumour organoid biobank provides a valuable tool to increase our understanding of the mechanisms driving cancer cachexia. Our preliminary characterization of the secretome of these organoids supports their application in functional studies including conditioned medium approaches and in vivo transplantation models.