Hepatectomy Followed by mFOLFOX6 Versus Hepatectomy Alone for Liver-Only Metastatic Colorectal Cancer (JCOG0603): A Phase II or III Randomized Controlled Trial.

Yukihide KanemitsuYasuhiro ShimizuJunki MizusawaYoshitaka InabaTetsuya HamaguchiDai ShidaMasayuki OhueKoji Komori Akio ShiomiManabu ShiozawaJun WatanabeTakeshi SutoYusuke Kinugasa Yasumasa TakiiHiroyuki BandoTakaya Kobatake Masafumi InomataYasuhiro ShimadaHiroshi KatayamaHaruhiko Fukudanull null

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)

DFS did not correlate with OS for liver-only metastatic CRC. Adjuvant chemotherapy with mFOLFOX6 improves DFS among patients treated with hepatectomy for CRC liver metastasis. It remains unclear whether chemotherapy improves OS.

Keyphrases

metastatic colorectal cancer
phase ii
randomized controlled trial
liver metastases
clinical trial
open label
phase iii
squamous cell carcinoma
study protocol
small cell lung cancer
phase ii study
placebo controlled
double blind
radiation therapy