GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15.
Caroline ChangYa-Yun ChengShriya KamlapurkarSierra R BrunoPriscilla W TangAmal Taher ElhawZaineb JavedKatherine Marie AirdKarthikeyan MythreyeRébécca PhaëtonNadine HempelPublished in: bioRxiv : the preprint server for biology (2024)
and that it regulates expression of GDF15. The immune profile associated with GPX3 expression in serous ovarian tumors suggests that GPX3 may be an alternate marker of ovarian tumors susceptible to immune check-point inhibitors.