Association of P2X7 receptor genetic polymorphisms and expression with rheumatoid arthritis susceptibility in a sample of the Iranian population: a case-control study.
Gholamreza BahariFarhad TabasiMohammad HashemiZahra ZakeriMohsen TaheriPublished in: Clinical rheumatology (2021)
Our results suggest that rs2393799, rs3751143, and rs2230912 variants of the P2X7 gene are associated with RA's susceptibility in a sample of the Iranian population. Also, P2X7 mRNA expression was higher in our new RA patients. The P2X7 receptor has been considered as a potential pharmacologic target in RA. Key Points • P2X7 variants (rs2393799, rs2230912, rs3751143) were associated with RA susceptibility in a sample of the Iranian population. • rs2393799 increases the risk of RA, while rs2230912 and rs3751143 decrease the risk of RA. • P2X7 expression was significantly upregulated in new RA patients compared to controls.
Keyphrases
- rheumatoid arthritis
- disease activity
- end stage renal disease
- ankylosing spondylitis
- ejection fraction
- newly diagnosed
- poor prognosis
- chronic kidney disease
- interstitial lung disease
- systemic lupus erythematosus
- risk assessment
- gene expression
- systemic sclerosis
- genome wide
- climate change
- transcription factor
- long non coding rna