Dose Comparison of Dexmedetomidine Sedation following Spinal Anesthesia: Parturient versus Nonpregnant Women-A Randomized Trial.
Ming XiongBiyun ChenZurong HuSomdatta GuptaZhitao LiJiping LiuJing HeShivani PatelJean Daniel EloyXiang LiPublished in: Anesthesiology research and practice (2020)
The ED50 of dexmedetomidine for target sedation in parturients who received spinal anesthesia for CS is greater than 1.5 times that in nonpregnant women who received spinal anesthesia for lower abdominal gynecologic surgery. This study postulates that the dose of dexmedetomidine required to achieve optimal sedation following spinal anesthesia is much higher in parturients than in nonpregnant women undergoing gynecologic surgeries. This trial is registered with NCT02111421.
Keyphrases
- spinal cord
- polycystic ovary syndrome
- pregnancy outcomes
- cardiac surgery
- mechanical ventilation
- emergency department
- minimally invasive
- clinical trial
- breast cancer risk
- insulin resistance
- endometrial cancer
- metabolic syndrome
- coronary artery bypass
- pregnant women
- randomized controlled trial
- spinal cord injury
- type diabetes
- coronary artery disease
- acute kidney injury
- adipose tissue