Colchicine's effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial.
Andrew Paul DemidowichJordan A LevineRichard AppsFoo K CheungJinguo ChenGiovanna Fantoninull nullTushar P PatelJack A YanovskiPublished in: International journal of obesity (2005) (2020)
In adults with obesity, colchicine significantly affected concentrations of proteins involved in the innate immune system, endothelial function and atherosclerosis, uncovering new mechanisms behind its cardiometabolic effects. Further research is warranted to investigate whether colchicine's IL-6 suppressive effects may be beneficial in COVID-19.
Keyphrases
- metabolic syndrome
- insulin resistance
- randomized controlled trial
- type diabetes
- weight loss
- immune response
- sars cov
- study protocol
- coronavirus disease
- cardiovascular disease
- high fat diet induced
- weight gain
- oxidative stress
- clinical trial
- uric acid
- systematic review
- adipose tissue
- body mass index
- cardiovascular risk factors
- physical activity
- respiratory syndrome coronavirus