Morphine Versus Oxycodone for Cancer Pain Using a Catechol-O-methyltransferase Genotype Biomarker: A Multicenter, Randomized, Open-Label, Phase III Clinical Trial (RELIEF Study).
Hiromichi MatsuokaJunji TsurutaniYasutaka ChibaYoshihiko FujitaKiyohiro SakaiTakeshi YoshidaMiki NakuraRyo SakamotoChihiro MakimuraYoichi OhtakeKaoru TanakaHidetoshi HayashiMasayuki TakedaTatsuya OkunoNaoki TakegawaKoji HarataniAtsuko KoyamaKazuto NishioKazuhiko NakagawaPublished in: The oncologist (2022)
Using the COMT rs4680 genotype alone is not recommended for selecting between morphine and oxycodone for pain relief.