Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles.
Bashar KhiatahMeirigeng QiWeiting DuKuan T-ChenKayleigh M van MegenRachel G PerezJeffrey S IsenbergFouad KandeelBart O RoepHsun Teresa KuIsmail H Al-AbdullahPublished in: Stem cell research & therapy (2019)
The results demonstrate that IPTD-MSCs reside within the pancreas and can be separated as part of a standard islet-isolation protocol. These IPTD-MSCs can be expanded and potentiated ex vivo to enhance their anti-inflammatory and pro-angiogenic profiles. The fact that IPTD-MSCs are generated in a GMP-compatible procedure implicates a direct clinical application.