A landscape review of malaria vaccine candidates in the pipeline.
Yusuf Amuda TajudeenHabeebullah Jayeola OladipoSodiq Inaolaji YusuffSamuel O AbimbolaMuritala AbdulkadirIyiola Olatunji OladunjoyeAbass Olawale OmotoshoOluwaseyi Muyiwa EgbewandeHameedat Damilola ShittuRashidat Onyinoyi YusufOluwatosin OgundipeAbdulbasit Opeyemi MuiliAbdullateef Opeyemi AfolabiSalwa M A DaheshMarwa Ahmed Mahmoud GameilMona Said El-SherbiniPublished in: Tropical diseases, travel medicine and vaccines (2024)
Malaria vaccine candidates targeting different lifecycle stages of the parasite range from chemoprophylaxis vaccination to cross-species immune protection. The use of a multi-antigen, multi-stage combinational vaccine is therefore essential in the context of global health. This demands careful understanding and critical consideration of the long-term multi-faceted interplay of immune interference, co-dominance, complementary immune response, molecular targets, and adjuvants affecting the overall vaccine-induced immune response. Despite challenges, advancements in clinical trials and vaccination technology offer promising possibilities for novel approaches in malaria vaccine development.