Physicochemical properties of fucoidan and its applications as building blocks of nutraceutical delivery systems.

Many bioactive ingredients with health effects such as antioxidant, anti-inflammatory and neuroprotective possess low bioavailability due to poor solubility and sensitivity. Fucoidan is an ideal material for encapsulating bioactive ingredients because of its unique physicochemical and biological properties, which can improve the function and application of bioactive ingredients. Nevertheless, there is still a lack of review about the physicochemical properties as well as functionalities of fucoidan and the application of fucoidan-based delivery systems in functional food. Hence, in this review, recent advances on the structure, chemical modification, physicochemical properties and biological activity of fucoidan are summarized. This review systematacially describes the recent update on the fucoidan as a wall material for delivering nutraceuticals with a broad discussion on various types of delivery systems ranging from nanoparticles, nanoparticle/bead complexes, emulsions, edible films, nanocapsules and hydrogels. Futhermore, the technical scientific issues of the application of fucoidan in the field of food are emphasized. On the basis of more comprehensive and deeper understandings, the review ends with a concluding remark on future directions of fucoidan-based delivery systems for purposes. Novel fucoidan-based delivery systems such as aerogels, Pickering emulsions, emulsion-filled-hydrogels, liposomes-in-fucoidan, co-delivery systems of bioactive igredients can be designed.