Expression analysis of HLA-E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis.

Alberto CauliGrazia DessoleMatteo PigaMaria Maddalena AngioniSilvia PinnaAlberto FlorisMattia CongiaEnrico MasciaFabiana PaladiniValentina TedeschiRosa SorrentinoMaria Teresa FiorilloAlessandro Mathieu

Published in: RMD open (2018)

The higher surface level of HLA-E molecules in patients with AS compared with HC, concurrently with a prevalent expression of NKG2A, suggests that the crosstalk between these two molecules might play a role in AS pathogenesis, accounting for the previously reported association between HLA-E and AS.

Keyphrases

ankylosing spondylitis
nk cells
natural killer cells
poor prognosis
rheumatoid arthritis
disease activity
long non coding rna
binding protein