Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes.
Michael M RichterMads N ThomsenMads J SkytteSasha A S KjeldsenAmirsalar SamkaniJan FrystykFaidon MagkosJens J HolstSten MadsbadThure KrarupSteen B HaugaardNicolai J Wewer AlbrechtsenPublished in: Journal of the Endocrine Society (2024)
The CRHP diet significantly reduced FGF21 in people with type 2 diabetes independent of weight loss, supporting the role of FGF21 as a "nutrient sensor." Combining metformin treatment with carbohydrate restriction and weight loss may provide additional metabolic improvements due to the rise in circulating GDF15.