Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome.
Rebecca A PorrittLisa PascholdMagali Noval RivasMary Hongying ChengLael M YonkerHarsha ChandnaniMerrick LopezDonjete SimnicaChristoph SchultheißChintda SantiskulvongJennifer E Van EykAlessio FasanoIvet BaharMascha BinderMoshe ArditiPublished in: bioRxiv : the preprint server for biology (2020)
Multisystem Inflammatory Disease in Children (MIS-C) patients exhibit T cell receptor (TCR) repertoire skewing, with expansion of T cell Receptor Beta Variable gene (TRBV)11-2TRBV11-2 skewing correlates with MIS-C severity and cytokine stormJ gene/CDR3 diversity in MIS-C patients is compatible with a superantigen selection process In silico modelling indicates TCR Vβ11-2 engages in CDR3-independent interactions with the polybasic insert P 681 RRAR in the SAg-like motif of SARS-CoV-2 spike.