Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia.

Mariam MurtadhaMiso ParkYinghui ZhuEnrico CasertaAda Alice DonaMahmoud SingerHawa VahedTheophilus TasndohAsaul GonzalezKevin LyJames F SanchezArnab ChowdhuryAlex PozhitkovLucy GhodaLing LiBin ZhangAmrita KrishnanGuido MarcucciAlexander PozhitkovFlavia Pichiorri

Published in: bioRxiv : the preprint server for biology (2023)

This work represents a potential advancement in the treatment of AML, as it involves the release of IFN-γ by T cells to induce CD38 expression and thus sensitizing leukemia stem cells, which have been resistant to current treatment regimens, to CD38-directed T cell engagers.

Keyphrases

stem cells
acute myeloid leukemia
bone marrow
immune response
dendritic cells
poor prognosis
cell therapy
combination therapy
allogeneic hematopoietic stem cell transplantation
mesenchymal stem cells
intensive care unit
smoking cessation
mechanical ventilation