Isolation of Hafnia paralvei co-harbouring bla NDM-1 and bla VIM-1 in a woman who underwent allogeneic hematopoietic stem cell transplantation.
Tobías Manuel AppelClaudia SteinChristian BrandtJürgen RödelJochen J FrietschJenny MiethkeAndreas HochhausInken HilgendorfPublished in: Infection (2023)
Metallo-β-lactamases (MBL) are a threat to public health, since they dramatically limit the use of β-lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome. Antimicrobial susceptibility testing yielded resistance to trimethoprim/sulfamethoxazole, colistin, fosfomycin and all β-lactams, except cefiderocol. Whole genome sequencing revealed the presence of plasmid-encoded NDM-1 and VIM-1 carbapenemases. This finding highlights the importance of epidemiological surveillance and new therapeutic options for MBL.
Keyphrases
- klebsiella pneumoniae
- allogeneic hematopoietic stem cell transplantation
- multidrug resistant
- gram negative
- public health
- acute myeloid leukemia
- drug resistant
- acute lymphoblastic leukemia
- acinetobacter baumannii
- case report
- escherichia coli
- global health
- crispr cas
- single cell
- rectal cancer
- cystic fibrosis
- pseudomonas aeruginosa