TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models.
Annika van HummelMiheer SabaleMagdalena PrzybylaJulia van der HovenGabriella ChanAstrid F FeitenRoger S ChungLars M IttnerYazi D KePublished in: Neuropathology and applied neurobiology (2023)
In summary, CCNF expression in mice reproduces clinical presentations of ALS, including functional deficits and TDP-43 neuropathology with altered CCNF-mediated pathways contributing to the pathology observed.