Truly Man's Best Friend: Canine Cancers Drive Drug Repurposing in Osteosarcoma.
Mia C WeissVanessa EuloBrian Andrew Van TinePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
While metastatic osteosarcoma is rare in humans, it is the most common bone tumor found in any breed of dog. Given the genetic similarities between canine and human osteosarcomas, canine clinical trials allow for rapid testing and drug repurposing at a speed that cannot be achieved using osteosarcoma patients.
Keyphrases
- clinical trial
- end stage renal disease
- endothelial cells
- ejection fraction
- newly diagnosed
- squamous cell carcinoma
- small cell lung cancer
- peritoneal dialysis
- bone mineral density
- prognostic factors
- gene expression
- randomized controlled trial
- young adults
- induced pluripotent stem cells
- soft tissue
- postmenopausal women
- quantum dots